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And lastly, clonidine improves neuraxial opioids and, in combination with fentanyl, interacts in an additive way, which could reduce the dose of each part by 60% for postoperative analgesia.Jun ten, 2024 · If clonidine therapy is to be replaced by a β-blocker, delay administration from the β-blocker for several times just after clonidine therap